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Nevertheless there is a theoretical risk for potentiation, since the herb is thought to be a coumarin constituent. However, because melatonin causes drowsiness, its use should be avoided or used with extreme caution with alcohol and other sedating medicines, such as: Examples of other herbs that can also lead to drowsiness include 5-HTP, kava, and St. Johns Wort. CYP3A4 inhibitors, such as grapefruit, can interact with certain medications by inhibiting the liver enzyme that metabolizes many drugs. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. 1993;31(7):607-611. The use of ginkgo extract dates back centuries in traditional Chinese medicine. Medical Content Reviewed By HelloPharmacist Bonilla DA, Moreno Y, Gho C, Petro JL, Odriozola-Martnez A, Kreider RB. View abstract. 2000 Dec;34(12):1478-82. doi: 10.1345/aph.10031. and transmitted securely. Potential herb-drug interactions are of a major safety concern, especially for drugs with narrow therapeutic indices like warfarin, which can lead to severe adverse reactions that are sometimes life-threatening. View abstract. Kamal HI, Patel K, Brdak A, Heffernan J, Ahmad N. Ashwagandha as a unique cause of thyrotoxicosis presenting with supraventricular tachycardia. 2005 - 2023 WebMD LLC. Upadhaya L and et al. Effects of ashwagandha (Withania somnifera) on physical performance: systematic review and Bayesian meta-analysis. Evid Based Complement Alternat Med. Always consult with your doctor or pharmacist to check for herbal and drug interactions with any medicines you take. Overall, ashwagandha doesn't seem to have many reported significant drug interactions. Sharada, A. C., Solomon, F. E., Devi, P. U., Udupa, N., and Srinivasan, K. K. Antitumor and radiosensitizing effects of withaferin A on mouse Ehrlich ascites carcinoma in vivo. Your last name and email address will not be displayed. There are many different types of choline supplements, but Alpha-GPC may just be superior. Tharakan A, Shukla H, Benny IR, Tharakan M, George L, Koshy S. Immunomodulatory Effect of Withania somnifera (Ashwagandha) Extract-A Randomized, Double-Blind, Placebo Controlled Trial with an Open Label Extension on Healthy Participants. Otherwise, side effects are both rare and mild and can usually be remediated by adjusting your dosing routine. *All products contain less than 0.3% 9THC. Indian J Exp Biol. Byetta, Trulicity, Ozempic, Rybelsus, Bydureron, Victoza, Mounjaro), Sulfonylureas (e.g. Be sure to let your doctor know if you plan on adding ashwagandha to your medication list so you can be appropriately monitored. Feverfew is a member of the daisy family. Deocaris, C. C., Widodo, N., Wadhwa, R., and Kaul, S. C. Merger of ayurveda and tissue culture-based functional genomics: inspirations from systems biology. 2019;11(12):e6466. Katz M, Levine AA, Kol-Degani H, Kav-Venaki L. A compound herbal preparation (CHP) in the treatment of children with ADHD: a randomized controlled trial. Phytomedicine 2000;7(6):463-469. In a review article published in March 2014, 38 herbs were reviewed and were found to clinically interact with warfarin. Further clinical trials are needed to prove the overall clinical effect of interactions between warfarin and herbal supplements. MedFacts Natural Products. Can you take ashwagandha and Orilissa together? View abstract. WebMD says it can interact with thyroid medicine, anti depressants, and immunosuppressants, it doesn't list any blood thinners (link at https://www.webmd.com/vitamins/ai/ingredientmono-953/ashwagandha), Jon Robertson use free eliquis coupon 2023 community. Taking ashwagandha with sedative medications might cause breathing problems and/or too much sleepiness. Jahanbakhsh SP, Manteghi AA, Emami SA, Mahyari S, et al. Large doses can lead to an upset stomach, diarrhea, vomiting, and, in rare cases, liver problems. View abstract. Remenapp A, Coyle K, Orange T, et al. View abstract. View abstract. If on warfarin.don't take anything without Dr supervision. The phase IV clinical study analyzes what interactions people who take Warfarin sodium and Maca maca have. The clinical effects of the herbs on warfarin were categorized as potentiation or inhibition. All rights reserved. If saw palmetto is combined with estrogens or oral contraceptives, the effectiveness of the hormonal therapies could be reduced. The interactions between warfarin and medicinal herbs described in the literature have been summarized in this paper relying on Medline database (via PubMed) using the key words: warfarin, herbal supplements and interactions. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. selective serotonin reuptake inhibitors (SSRIs), slow down the absorption of iron from your body, Top 9 Ways to Prevent a Deadly Drug Interaction. This product may interfere with some lab tests. Yohimbe is the name of an evergreen tree that is found in some African countries. As always, be sure to talk to your doctor about combining any over-the-counter dietary supplement with your prescribed drugs as they have your complete medical profile. ConsumerLab.com's answer explains. There is no drug interaction reported. Take extra care driving and doing tasks that you need to be alert for while taking this product. Sehgal, V. N., Verma, P., and Bhattacharya, S. N. Fixed-drug eruption caused by ashwagandha (Withania somnifera): a widely used Ayurvedic drug. Likewise, the effects of ashwagandha in nursing . Feel free to send him an email at Hello@HelloPharmacist.com! For example, kratom is one example that has been involved in many seizures. Cooley K, Szczurko O, Perri D, et al. Do not use this product if you are pregnant or plan to become pregnant soon. If you are considering the use of any supplement, always check with your doctor first. View abstract. Effect of an ashwagandha (Withania Somnifera) root extract on climacteric symptoms in women during perimenopause: A randomized, double-blind, placebo-controlled study. Would you like email updates of new search results? The https:// ensures that you are connecting to the J Funct Morphol Kinesiol. J.Altern.Complement Med. Herbs that may potentiate the effect of warfarin, increasing the risk for bleeding, are listed in Online Table 1.1-3 The potentiation was classified as major, moderate, minor, or non-clinical.2 Major potentiation was defined as death, major bleeding, or the need to interrupt warfarin therapy due to serious bleeding.2 Moderate potentiation was defined as an international normalized ratio (INR) that requires a dosage adjustment. Check with your health care provider before using feverfew; you can check for other drug interactions with feverfew here. View abstract. The comparative effect of milk fortified with Aswagandha, Aswagandha and Punarnava in children - a double-blind study. The use of the eHealthMe site and its content is at your own risk. Ashwagandha contains several active constituents including: The mechanism of how ashwagandha works, for all of its purported benefits, is not well understood. MeSH hydrochlorothiazide, spironolactone, chlorthalidone). Biomed Res Int 2015;2015:284154.View abstract. View abstract. Singh P, Salman KA, Shameem M, Warsi MS. Withania somnifera (L.) Dunal as add-on therapy for COPD patients: a randomized, placebo-controlled, double-blind study. Neurol India 2009;57:166-71. 1965;9(1):9-15. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Panda S, Kar A. Withania somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice. Indian J Physiol Pharmacol. Herbal supplements are sold in many different forms - dried leaves for teas, powdered, as capsules or tablets, in solution, or even as gummies or chewing gum. The use of herbal supplements is becoming a major safety concern because drugherbal interactions can cause serious adverse events. Medicine (Baltimore). Warfarinherbal interactions can be classified based on pharmacokinetics and pharmacodynamics.2 Pharmacokinetic interactions involve the processes by which warfarin is absorbed, distributed, metabolized, and excreted.2 Warfarin is metabolized by cytochrome P450 isoenzymes (CYPs), with CYP2C9 being responsible for the majority of the metabolism of the S-enantiomer of warfarin, which is more potent than the R-enantiomer.2 Herbal supplements that have an effect on CYP3A4 or CYP2C19 are also expected to affect the plasma concentration of warfarin.2 These supplements alter warfarin plasma concentration through the inhibition or induction of warfarin protein binding. Sedatives: Since ashwagandha can both energize and induce restorative sleep, it might negate or amplify the effect of other sedative drugs, especially the benzodiazepines. **, Press J to jump to the feed. V. The effect of total alkaloids (ashwagandholine) on the central nervous system. ashwagandha and coumadin interaction. WE CANNOT DIAGNOSE YOU OVER THE INTERNET. Studies are inconclusive, but ashwagandha may have immune-stimulating properties. Very bad throwing up Very bad loose stools Change in balance, feeling shaky, or unsteady Not able to think clearly or change in thinking Its effect on arterial blood pressure in anaesthetized dogs. eCollection 2022. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. J Ethnopharmacol 1999;67:27-35. Minor potentiation was defined as an INR that does not require a dosage adjustment. Durg S, Bavage S, Shivaram SB. Herbal supplements are not subject to review by the FDA and their use can often be risky. These products are intended for use and purchase only by persons 21 and older as in selected States. Effect of Asian ginseng, Siberian ginseng, and Indian ayurvedic medicine Ashwagandha on serum digoxin measurement by Digoxin III, a new digoxin immunoassay. ConsumerLab.com uses JavaScript to provide the best possible experience for our content, but your browser has it disabled. Side effects like respiratory distress, profound sedation, coma, and even death may occur. Changes in thyroid hormone concentrations after administration of ashwagandha root extract to adult male mice. Germany's Commission E, the authorities that evaluate the use of herbal products in Germany, has approved valerian as an effective mild sedative and it is used for insomnia. View abstract. Baker C, Kirby JB, O'Connor J, Lindsay KG, Hutchins A, Harris M. The perceived impact of ashwagandha on stress, sleep quality, energy, and mental clarity for college students: qualitative analysis of a double-blind randomized control trial. J Ethnopharmacol. 2017 Jan;22(1):96-106 View abstract. View abstract. Venkataraghavan S, Seshadri C, Sundaresan TP, and et al. This site is intended for informational purposes only and not to provide medical advice. Int.J.Crude Drug Res. Garlic supplements are sold over-the-counter, usually in tablet or capsule form. Health Sci Rep 2022;5(4):e741. No. Follow-up and management of valvular heart disease patients with prosthetic valve: a clinical practice guideline for Indian scenario. Withania somnifera extract. There is some preliminary research that it may help with epilepsy and memory loss, but these results are too early to say for sure if it could benefit humans. Caffeine capsules are easy to come by, and it's trivially easy to buy or package up ashwagandha powder in capsule form. **If you feel like you might have a medical emergency, then you should absolutely contact your doctor or go to your local ER/Urgent care. Recognition of the adverse effects of medicinal herbs is not routine and the reports on such effects are even less frequent in clinical practice. It is often used in blood clots. I am wondering if it is okay to take with my prescriptions. View abstract. Medically reviewed by Leigh Ann Anderson, PharmD. Indian J Exp Biol 2000;38:607-9. Although data is conflicting, some studies have shown cranberry can reduce recurrent UTIs in pregnant women, the elderly and hospitalized patients; but it is not helpful to. Some mixtures of medications can lead to serious and even fatal consequences. Some of these medicine interactions can be risky. Chauhan S, Srivastava MK, Pathak AK. Black cohosh is a shrub-like plant found in North America. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Office of Dietary Supplements. Lab studies suggest feverfew may increase the risk of bleeding, especially in people with blood-clotting disorders or using blood thinners to help prevent clots. Pharmacol Biochem.Behav 2003;75(3):547-555. J Clin Med 2021;10(16):3644. Costache II, Miron A, Hncianu M, Aursulesei V, Costache AD, Aprotosoaie AC. 2012;7(9):e44419. Yes, the effectiveness of warfarin (Coumadin), anisindione (Miradon) and other anticoagulant drugs prescribed to help prevent blood clots can be impacted by taking supplements. Ashwagandha might lower blood pressure. government site. Effect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients. Especially if you're sensitive to your blood thinner already. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. There are 326 drugs known to interact with dextromethorphan, along with 1 alcohol/food interaction. Symptoms of an allergic reaction to Ashwagandha may include: Swelling of the lips, mouth, and airways Difficulty breathing Skin rashes or hives Runny nose Watery eyes Nausea and vomiting Stomach cramping Bloating Loose stools Interactions With Other Supplements or Medications Cureus. The FDA does not apply the same effectiveness and safety studies used for prescription drugs to herbals, dietary supplements, and their manufacturers. Nat.Prod.Res 2005;19(6):567-571. You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood. J Atten Disord 2010;14:281-91. Stood up and gave a speech in front of 75 people without a single jitter for the first time in my life. It is not meant to be comprehensive and should be used as a tool to help the user understand and/or assess potential diagnostic and treatment options. Does Ashwagandha supplementation have a beneficial effect on the management of anxiety and stress? https://www.wolterskluwer.com/en/know/clinical-effectiveness-terms. Taking ashwagandha along with these medications might decrease the effects of these medications. 2003;19(3):211-222. Common uses for goldenseal include skin infections, for cold and flu symptoms, and to treat diarrhea, but evidence is weak for these uses. View abstract. J Evid Based Complementary Altern Med. Over 500 drug interactions exist with St. John's Wort and some can be dangerous. Biogerontology. There is concern that black cohosh might also be toxic to the liver and may rarely enhance liver toxicity with certain medications, such as: Signs of liver disease include fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, pale stools, and/or yellowing of the skin or eyes. 8-19-2005;334(1):276-287. 2020. Indian J Thorac Cardiovasc Surg. Drug interactions with herbs can be especially risky, too. Akhgarjand C, Asoudeh F, Bagheri A, et al. If you are being treated for depression, speak to your doctor before you use yohimbine or any herbal supplement. Over-the-counter supplements are not approved for safety or effectiveness by the FDA before they hit the market, and some may contain tainted chemicals or even illegal prescription drugs. View abstract. Because it can be affected by a large number of herbs, supplements and foods, it's important to consult your physician before taking any supplement with warfarin. The effect of total alkaloids on the smooth muscles. Learn how to enable it, Digestive enzymes (i.e. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Ashwagandha may have additive effects to certain drugs that are used for diabetes, high blood pressure, and low thyroid hormone, to name a few. Elite Continuing Education CE. Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study. Women who are breastfeeding should also not use the herb.. Therefore, it should be used cautiously with drugs used to treat diabetes, including: Just like with potential interactions between ashwagandha and diabetes drugs, there may be a potential issue with drugs used to treat high blood pressure as studies show ashwagandha mayhave blood-pressure-lowering effects. Because it can be affected by a large number of herbs, supplements and foods, it's important to consult your physician before taking any supplement with warfarin. p.46-62. Find the best products with instant access to our latest tests & reviews of over 1,300 health products. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. I take warfarin (Coumadin), an anticoagulant drug. I have been prescribed Wellbutrin XL for panic att My son, who weighs 78 lbs, was diagnosed with strep throat on Tuesday. Deshpande A, Irani N, Balkrishnan R, Benny IR. Potential interactions between alternatives therapies and warfarin. We comply with the HONcode standard for trustworthy health information. 1996;35(1):95-100. J Med Food 2022. Arch Intern Med 1998:158;2200-11. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy. While avoidance of medications in pregnancy is the best course of action, this is not Society tends to treat menopause as a disease; something to be avoided at all costs. There are over 100 possible drug interactions with goldenseal, have your pharmacist check for drug interactions with all your medicines. What are the risks of taking ashwagandha? All rights reserved. Malhotra, C. L., Mehta, V. L., Prasad, K., and Das, P. K. Studies on Withania ashwagandha, Kaul. People use ashwagandha for other health conditions, including anemia. View abstract. The .gov means its official. 2021 Nov 25;13(2):100510. WebMD says it can interact with thyroid medicine, anti depressants, and immunosuppressants, it doesn't list any blood thinners (link at https://www.webmd.com/vitamins/ai/ingredientmono-953/ashwagandha) direebn 3 days ago Im on warfarin, so there are a ton of drug interactions. We can, however, make some educated guesses on drug interactions based on ashwagandha works, and the effects it is known to have. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat. In large amounts or when using a poor-quality formulation, Ashwagandha may cause some mild side effects, including: Although side effects are rare in general, nausea and diarrhea are the most common possible side effects of Ashwagandha. St. Johns Wort is a popular herbal supplement widely used to help with symptoms of depression. all maps fatal bullet; who is running for senate in maryland 2022 Be alerted to newclinical findings & warnings. Long term effect of herbal drug Withania somnifera on adjuvant induced arthritis in rats. Enter other medications to view a detailed report. Enter other medications to view a detailed report. Drug interactions with ginger are not well documented; however, it is known to inhibit thromboxane synthetase, which can prolong bleeding time and may rarely cause interactions with anticoagulants like warfarin, aspirin, or other blood thinners. There are over 180 drug interactions with garlic, but most are reported as minor. There aren't any specific antidiabetic drugs ashwagandha is known to interact with. Cranberry may exert an increased effect on blood thinners (anticoagulants) like warfarin and lead to bruising or bleeding. There are 626 drugs known to interact with Remeron (mirtazapine), along with 13 disease interactions, and 2 alcohol/food interactions. Malhotra, C. L., Mehta, V. L., Das, P. K., and Dhalla, N. S. Studies on Withania-ashwagandha, Kaul. Investigation of CYP2B6, 3A4 and -esterase interactions of Withania somnifera (L.) dunal in human liver microsomes and HepG2 cells. Consumers need to understand that even though the label may say "natural", these products are not always safe, as demonstrated by "all natural" alternatives sold OTC for erectile dysfunction that the FDA found contained actual prescription medications. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. No cases have been reported of Matricaria chamomilla potentiating the effects of warfarin. Now, most studies suggest that ashwagandha doesn't have significant blood pressure lowering effects, so the interaction here is thought to be relatively mild. HHS Vulnerability Disclosure, Help Although ashwagandha is one of the more well-studied herbals on the market, there have not been extensive drug-interaction studies with it. metoprolol, nebivolol, propranolol), Diuretics (e.g. Kelgane SB, Salve J, Sampara P, Debnath K. Efficacy and tolerability of ashwagandha root extract in the elderly for improvement of general well-being and sleep: A prospective, randomized, double-blind, placebo-controlled study. Mycelium vs Fruiting Body: Which Mushroom Supplements are the Best? Please do not submit any type of HTML markup or scripting as it will not be accepted, nor will posts that exceed 2,500 characters. If you make a statement of fact, such as whether a type of treatment does or does not work, state your basis -- such as personal experience or a published study. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Choline vs Alpha-GPC: Which is the Superior Cholinergic? Talk to your doctor before using kava. Available for Android and iOS devices. View abstract. We study 132,077 people who take Ashwagandha or Coumadin. Still, best to proceed with caution. Phytother Res 2022. 2004;42(12):2015-2020. If you have blood sugar problems, keep hard candies, glucose tablets, liquid glucose, or juice on hand for low blood sugar. Blog Uncategorized ashwagandha and coumadin interaction Uncategorized ashwagandha and coumadin interaction Research has shown that Ginkgo Biloba is not likely to be effective in treating heart disease. Memorial Sloan-Kettering Cancer Center web site: About Herbs: Ashwagandha., Natural Medicines Comprehensive Database web site: Ashwagandha., Natural Standard Patient Monograph: Ashwagandha.. Hu Z, Yang X, Ho PC, Chan SY, Heng PW, Chan E, Duan W, Koh HL, Zhou S. Drugs. We study millions of patients and 5,000 more each day. Keep out of reach of children. Does Remeron interact with my other drugs? Drugs.com. Ashwagandha may have additive effects to certain drugs that are used for diabetes, high blood pressure, and low thyroid hormone, to name a few. Learn more about vitamin K, including info on interactions with blood thinners such as Coumadin and Jantoven, its effects on bones & impact on clotting. Liver Int. Save money by finding high-quality products at lower cost. On xarelto, I've used plenty of herbs, including ashwagandha with no problems. Richards JS. Ask your doctor for advice about forms of ashwagandha and doses. Ashwagandha May Interact With Certain Drugs Ashwagandha may interact with certain drugs by enhancing or negating their actions. Interactions of warfarin with garlic, ginger, ginkgo, or ginseng: nature of the evidence. Seek immediate medical attention if you experience any signs and symptoms of bleeding such as: Learn More: Melatonin: Worth Losing Sleep Over? J Ethnopharmacol. Therapy with yohimbine is generally not recommended in patients with hypertension, angina, or heart disease because it has a stimulatory effect and can lead to high blood pressure and a rapid heart rate. It seemed high to me too, when I asked for beta blockers, my doctor said he'd prescribe 40mg, to which I replied 'that seems a bit high, I read online that 10mg-20mg is effective for public speaking', but he just shook his head and said 'you wouldn't even be able to . Again, be sure to talk to your doctor about adding ashwagandha to immunosuppressant drugs. They do list some herbs in the drug interactions section (e.g., St. John's Wort) but ashwagandha is not listed. Even the simple, delicious cranberry can have drug interactions. Garlic is a commonly used flavoring agent, food product and herbal supplement. To prevent unnecessary adverse drug interactions, health care professionals need to be proactive in caring for their patients. Learn about the different forms of vitamin K2 - MK-4 (synthetic) and MK-7 (natural, from natto). Please enable it to take advantage of the complete set of features! Indian J Psychol Med. You can check for other evening primrose oil drug interactions here. Today, ginseng use is reported to improve the body's resistance to stress and increase vitality, among other uses. All information is observation-only. Altern Med Rev 2000;5:334-46. 2020;12(4):1119. It's not clear which of the ingredients had the benefit since ashwaganda is traditionally used in combination with other herbs. Take extra care if you are using drugs to help you relax or sleep. Ashwagandha is an evergreen shrub that grows in Asia and Africa. Different individuals may respond to medication in different ways. Nutrients. Even though herbal supplements may be from plant or herb sources, the active ingredients can still be potent chemicals. . Another way to take the two together is with capsules. Bhattacharya SK, Satyan KS, Ghosal S. Antioxidant activity of glycowithanolides from Withania somnifera. Yohimbine can dilate blood vessels and is often promoted for erectile dysfunction (ED) or sexual problems caused by some antidepressants like selective serotonin reuptake inhibitors (SSRI) antidepressants. You may need to have your blood clotting tests checked more frequently and may need a change in your anticoagulant dose. This includes people who have had a transplant, are on chemo, or have an autoimmune disease. Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. We describe the case of a 70-year-old woman who, while being treated with warfarin, was admitted to hospital with multiple internal . Does methotrexate interact with my other drugs? Kulkarni, S. K. and Dhir, A. Withania somnifera: an Indian ginseng. Create an account to follow your favorite communities and start taking part in conversations. J Med Food 2022. Can You Take Ashwagandha And Orilissa Together? It isn't known if ashwagandha will help people with cancer. If you take an oral blood thinner, check with your doctor before consuming unusual amounts of cranberry or cranberry juice. Begum, V. H. and Sadique, J. ConsumerLab.com name and flask logo are both registered trademarks of ConsumerLab.com, LLC. Supplements that may interact with these medications include fish oil and St. John's wort. Are there supplements I should avoid, or be taking, due to this drug? Currently on week 5 20mg Prozac and 600mg ksm-66 ashwagandha daily. It may be used by some people to help with rheumatoid arthritis and nerve pain in diabetes, also called diabetic neuropathy.. Evening primrose oil provides fatty acids used by the body for growth. As with many herbal products, blood clotting may be affected with use of melatonin with anticoagulants such as warfarin. lisinopril, captopril, benazepril, quinapril), ARBs (e.g.