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Treatment may then be continued at the same dose given once a day. 15. Many of these cytokines bind to cytokine receptors that have JAK enzymes associated with their cytoplasmic portion. She reports choosing Apoquel over corticosteroids in several of her allergic patients that are also at risk for developing laminitis. Generally self-limiting and harmless, hives are nonetheless uncomfortable and can occasionally lead to angioedema (swelling under the skin) or purpura (blood vessels rupturing and leaking blood internally). White believes that while further research in horses is warranted, veterinarians should consider latex exposure a potential risk to equine respiratory health. Nobody wants to be itchy and constantly scratching. This regimen may work better because oclacitinib has a short half-life of 4 hours. Oclacitinib can be given without food and may be discontinued without tapering. 1. You'd do anything for your pet. This encourages the natural drainage of irritants, allergens, and bacteria from the airways.. 4. Submit Office Orders & Patient Prescriptions. Collard WT, Hummel BD, Fielder AF, et al. Oclacitinib is available in 3 different tablet sizes: 3.6, 5.4, and 16 mg. Pollen and other plant-based aeroallergens are the source of their distress, and they fare much better inside, Many allergens can cause skin reactions. Thereafter the dose should be reduced to once daily for maintenance. Wedgewood Pharmacys compounded veterinary preparations are not intended for use in food and food-producing animals. Dexamethasone is a synthetic corticosteroid hormone used to manage inflammation in diseases or conditions in which the immune system has a significant role. Remove all nonessential supplements and topical solutions from your horses diet and routine. Proc (Bayl Univ Med Cent) 2018;31(4):524-525. Specifically, studies in cats have used the following dosage: Initially, doses ranging from 0.4 to 1.2 mg/kg body weight, twice daily, for 24-28 days. At that point, the treatment can be changed to oclacitinib. All rights reserved. Its important to know, however, that some horses can have BOTH types, and will need to managed year-round!What are your treatment and management options? You can give your dog Apoquel with or without food. Since oclacitinib is a rather weak anti-inflammatory drug, it was suggested that remission of active moderate to severe atopic dermatitis be induced with a course of a broad inflammation-targeting drug, such as a short-acting glucocorticoid, until clinical signs become mild. I have not tried to go less than that. For the first two weeks, this is to be given twice per day, and then once per day after the first two weeks for maintenance. Atopic dermatitis is often a complex disease that requires a multifaceted approach. I actually have 2 horses now on serum and one I eliminated the food specific allergens from his diet. Vet Dermatol 2015;26(1):23-30, e7-8. 25. The dose range is very strict, I do not recommend going above the recommended dose due to immune suppression, below the range and it doesn't seem to work in most cases. actually treats degenerative joint disease (DJD), not just its clinical signs. And some can got a lower dose or a further spread out dose. Left untreated, these conditions can not only cause discomfort but also lead to raw, broken skin that allows bacteria to invade and infect. Immunomodulatory in vitro effects of oclacitinib on canine T-cell proliferation and cytokine production. U.S. Food and Drug Administration Center for Veterinary Medicine 7500 Standish Place Rockville, MD 20855 www.fda.gov . This site is for US animal healthcare professionals. Topical suspension administered in the ear. Breeding and Reproduction Horse breeding from planning through foal care; Diseases and Conditions Horse-health-problem risk factors, prevention, diagnosis, and treatment; Farm and Barn . Cosgrove SB, Cleaver DM, King VL, et al. Equine Asthma- yep, that's the new name for "heaves," "RAO," "COPD" or whatever else we've called it over the years! Pulsoni D, Freire A, Ferreira DR. Juvenile-onset ischemic dermatopathy. Find out more. Unlike steroids, the drug has minimal impact on the immune system. Levy BJ, Linder KE, Olivry T. The role of oclacitinib in the management of ischaemic dermatopathy in four dogs. Shes on 5 pills once a day for 7 days, after that we will drop to every other day, and then see how far we can space it out. When working with a liquid: Multiply your horse's weight in pounds times the dose rate in milligrams per pound. In cats, this medication can cause excitement rather than sedation. There are two types of this condition, summer-pasture-associated and classic recurrent airway obstruction (RAO). Treatment will probably need to repeated somewhere between 1 and 6 weeks after the initial treatment course. Minimum order 6 tablets per dosage. Olivry T, Banovic F. Treatment of canine atopic dermatitis: time to revise our strategy? 2: The Barn and Pasture: Horses with Summer-Pasture-Associated disease usually have less symptoms when kept in the barn during the warmer months. 2022 Zoetis Services LLC. IgE binds to cells in the body and releases inflammatory molecules. Avoid storing hay in the same barn as sensitive horses. Vet Dermatol 2015;26:134 (abstract). Gonzales AJ, Bowman JW, Fici GJ, et al. has been administered by veterinarians to help horses of . Previcox is an FDA-approved non-steroidal anti-inflammatory (NSAID) prescription medication used in dogs to treat pain and inflammation associated with osteoarthritis and for the control of postoperative pain and inflammation associated with soft-tissue and orthopedic surgery. Vet Dermatol 2015;26(3):171-179, e35. Thats def not nothing but its not insane. Safety & Side Effects Apoquel is safe to use in dogs one year and older. The Janus kinases (Jaks). Initially, the recommended dose of 0.4 to 0.6 mg/kg should be given twice daily for up to 14 days. Unlike steroids, the drug has minimal impact on the immune system. Luckily most of her allergies appear to be insect-based and she responds very well to the serum for that. Insect and pollen season is here. Look for a supplement with at least 1,500mg of DHA per serving. Dosage Chart One of the things the trials found on using apoquel with horses is that they need a relatively small dose. Apoquel is used to treat and control itching and inflammation in dogs resulting from a variety of causes, including environmental allergies, food allergies, flea allergy, and contact allergies. RELATED CONTENT | Infographic: Equine Allergies. In this study, 70% of the study population receiving oclacitinib showed improvement in pruritus compared with 75% in a group receiving methylprednisolone.18 Based on this study, a higher dose with a longer induction period seems to be the key to successfully treating feline pruritus with oclacitinib. If the patient remains stable and other controlling measures-such as allergen avoidance, allergen immunotherapy, and preventive topical therapyhave been implemented, the use of oclacitinib can be limited to flare control.16, Although oclacitinib is licensed for use in dogs, it has been reported to be effective to treat pruritus in allergic diseases in other species, including cats.17-20 shutterstock.com/Thrithot, Although oclacitinib is licensed for use in dogs, it has been reported to be effective to treat pruritus in allergic diseases in other species, including cats.17-20. Simple strategies for dust reduction include removing the horses from the stalls when mucking out and blowing the aisle or ditching the leaf blower altogether, Fultz says. We cannot be sure of accurate dosing when tablets are quartered, and thus this practice is not recommended. You are encouraged to speak with your prescriber as to the appropriate use of any medication. I hear the result have been spectacular. Allergies primarily affect the immune, respiratory, and integumentary (skin) systems and, if unmanaged, can seriously impact an animals performance and well-being. 9. Diphenhydramine can alter the results of skin allergy testing; discontinue this medication at least 2 weeks before testing. Assuming you cannot contact your vet: For hives or possible allergic airway disease (heaves), for a 1000 lb horse, give 5-10 tabs of 25mg diphenydramine crushed up and mixed in water and dosed in a syringe orally (by mouth). Vet J 2016;207:29-37. 9. Little PR, King VL, Davis KR, et al. Typically, a few sessions are required. Noli C, Matricoti I, Schievano C. A double-blinded, randomized, methylprednisolone-controlled study on the efficacy of oclacitinib in the management of pruritus in cats with nonflea nonfood-induced hypersensitivity dermatitis. Most recently, it was suggested that the treatment strategy for canine atopic dermatitis might need to be adjusted. Oral . Meaning, if a 100lbs dog gets 16mg (1 pill), a horse does not need 160mg (10 pills). Yamaoka K, Saharinen P, Pesu M, et al. Apoquel is an anti-allergy drug that's often prescribed by vets. 24. Several reports of successful use of oclacitinib to treat other diseases have been published.22-29 They include several cases of immune-mediated vascular diseases: idiopathic ear tip vasculitis in 4 dogs26 and ischemic dermatopathy in 6 dogs.28,29 In these reports, other classic medications had failed to control the disease until oclacitinib was added. 28. Your veterinarian also may use dexamethasone in high doses in emergencies for anaphylactic reactions, spinal cord trauma or shock. Topics. Hay replacement consists of any of the following: a complete pelleted diet, soaked alfalfa cubes, hay pellets, or possibly a bagged forage product like Chaffhaye. One of the things the trials found on using apoquel with horses is that they need a relatively small dose. My dog has been on apoquel for about 2 years. 1. Oclacitinib is well tolerated and, compared with classic allergy medications such as glucocorticoids and cyclosporine, equally effective in controlling pruritus. These and other kinase-inhibiting drugs sometimes work very well to stop the itching. Frank RK, Galvan BA, Schoell AR, et al. While easy to perform, Fultz says its not always accurate at predicting the exact allergens. Pros and cons of oclacitinib therapy. It is no surprise we see this omega-3-rich plant with anti-inflammatory and antioxidative properties in many skin and allergy supplements. 30. Apoquel can be administered with or without food. The recommended Apoquel dosage for dogs is 0.18 to 0.27 mg per lb of body weight (0.4-0.6 mg/kg) once a day. Collard WT, Hummel BD, Fielder AF, et al. Summer-pasture-associated horses tend to be triggered by spring/summer allergens like grasses and trees, and classic horses tend to be triggered by barn dust and mold spores. Im not dealing with food allergies but both the company and the vet did not recommend allergy shots for my mare. Adding an update here in case its helpful for others. Now divide the 10,000 mg by the 500 mg in the concentration. Equine Nutrition FAQ Series, sponsored by Purina Animal Nutrition. More severe ones, however, can truly take a toll on your horses health and make him miserable. If your horses allergies are seasonal, talk to your veterinarian about steps you can take to stay ahead of them. Therefore, it is recommended that dogs 6.6-9.9 lbs take of a 3.6 mg tablet twice daily as an initial dosage. Im hoping those are things I can stop giving, so that will help some with overall cost. Meaning, if a 100lbs dog gets 16mg (1 pill), a horse does not need 160mg (10 pills). 22. Avoid giving the medicine twice daily long-term. Feline idiopathic ulcerative dermatosis treated successfully with oclacitinib. Efficacy and safety of oclacitinib for the control of pruritus and associated skin lesions in dogs with canine allergic dermatitis. Currently, White is part of a team evaluating the possibility of delivering allergy shots in the form of a juice squirted under the horses tongue. Then, doses ranging from 0.4 to 1.2 mg/kg body weight once daily. Copyright 2023 Today's Veterinary Practice Web DesignbyPHOS Creative. K. Route of Administration . Speak to yourveterinarian in an emergency. Then reintroduce each, one by one, while monitoring for hives or other signs of allergies. Apoquel is the brand name of oclacitinib, a dog medication designed to relieve itching associated with allergies in dogs, particularly canine atopic dermatitis. The Janus kinases (Jaks). Apoquel is a dog allergy medicine used to treat and control chronic manifestations of allergic and atopic dermatitis in dogs. Most common side effects are vomiting and diarrhea. Rest assured, your horses are receiving the best possible disease protection. This product is a hand-held device that administers an anti-inflammatory mist into the horses nostril. Therefore, it is important to get your veterinarian involved right away. Fortunately, these side effects are relatively uncommon. We have limited her exposure to the type of grass that she is most allergic to (bermuda), but it is hard to actually remove her exposure to her allergens entirely. The efficacy and safety of oclacitinib have been assessed in various studies. Soaking hay can be time-consuming but is vital to helping horses that are showing signs of respiratory allergy., Feeding hay at ground level offers an added benefit: To maximize respiratory health, horses should spend portions of the day with their heads down, the way nature intended, she adds. To overcome its delayed effect, cyclosporine is often initially combined with other drugs such as prednisolone to accelerate the anti-inflammatory and antipruritic effects. Because insects are omnipresent in the horses environment at least some portion of the year, IBH is particularly labor-intensive to manage. So lets review why allergies happen, how they affect your horses body, and how to treat themor, better yet, how to avoid them altogether. Most horses in our area of North Carolina are "Summer-Pasture-Associated" asthma patients, so we recommend starting yearly treatment or management in March or April. These animals require the opposite regimen. There is a new drug available to help allergic horses: Apoquel. to 14 days, and then administered once daily for maintenance therapy. It is an anti-inflammatory drug from the class of drugs known as Janus kinase (JAK) inhibitors. Her allergies have reared their ugly heads again - no jowl pyoderma, but ears itching. The recommended dosage of Apoquel 3.6mg tablets is 0.18 to 0.27 milligrams per pound of body weight. Qualifies for Zoetis Petcare Rewards! It is most risky in horses that have metabolic disease like Equine Metabolic Syndrome (insulin resistance), PPID (cushings), or those that are overweight. Many allergens can cause skin reactions. "Even though the drug is currently labeled for use in dogs (with. Because its essentially impossible to predict these events, its important to keep records of your horses previous reactions and communicate them to your veterinarian. Most common side effects are vomiting and diarrhea. Apoquel For Dogs: Dosage Apoquel comes in three tablet sizes: 3.6mg, 5.4mg, and 16mg. The only FDA-approved equine PSGAG. Apoquel is sold per tablet in strengths of 3.6 mg, 5.4 mg, or 16 mg. Really? Vercelli A, Cornegliani L. Use of oclacitinib in treatment of canine idiopathic ear tip vasculitis. Transdermal applicator designed for easy handling and accurate dosing. 6. 15. Hydroxyzine is usually given orally twice to three times daily in dogs, cats, horses and birds. In more severe cases, Apoquel can be given twice per day. Yes, we looked into this approach, but unfortunately it was not a viable option for my horse for a variety of reasons including other health factors and severity of allergies. All product and company names are trademarks or registered trademarks of their respective holders. The second option is serum (blood) testing. Vet Dermatol 2013;24:48-e12. This treatment is typically effective, but the steroid is still absorbed into the body, which can result in laminitis risk, similar to Option 1. Repeated oral dose tolerance in dogs treated concomitantly with ciclosporin and oclacitinib for three weeks. Every cough means something is a common saying among equine veterinarians. 4. Dosage and treatment schedule The recommended initial dose is 0.4 to 0.6 mg oclacitinib/kg bodyweight, administered orally, twice daily for up to 14 days. Adverse events were reported in less than 5% of dogs, including urinary tract infection, vomiting, otitis, pyoderma, and diarrhea. This option has somewhat fewer risks than option 1, has a higher initial cost ($1,000 for the nebulizer mask), but a lower monthly cost- $20-$40/month. Oclacitinib should not be given in dogs younger than 12 months of age due to an increased risk for activating demodicosis, bacterial pneumonia, and other serious infections. A Magnawave-certified practitioner, Lucile also runs a small equine PEMF therapy business. Frank RK, Galvan BA, Schoell AR, et al. Food allergies in particular you cant always do the serum for. Apoquel is a prescription dog allergy medicine used for the control of itch associated with allergic dermatitis and control of atopic dermatitis in dogs 12 months and older. Ive used it on a couple of mine, and I also have some friends who have done it. Although no studies of pharmacokinetics in cats have been published, oclacitinib is well tolerated and seems to be safe when used in cats at 1 or 2 mg/kg q12h for 28 days. The efficacy of oclacitinib was also compared to that of other drugs such as prednisolone and cyclosporine. Have you considered trying allergy testing? 13. Maintaining Your Horses Weight During the Winter, Special Report: Preventing 3 Common Equine Joint Issues, JACKSON- Gelding/Bay/Mustang (Nevada) - Project/Ready for Training, JENNINGS Gelding/Cremello/Mustang (BLM) Ridable (Green), recent study evaluating almost 400 potential allergens, BONNIE: Sorrel Mustang Mare Non-Riding Companion Only. Powered by Discourse, best viewed with JavaScript enabled. Recently, researchers have delved into the causes and consequences of what now falls under the umbrella term equine asthma. I had a cat on it years ago and it was $$$$ but it was the only thing that worked for her. 18. Many allergic reactions are evident as a mild case of transient hives. The dosage for dogs 15-19.9 lbs is one 3.6 mg tablet twice daily. While this is a very important strategy for some types of Equine Asthma ("classic" RAO), it may not be as important when managing those with Summer-Pasture-Associated disease. In many cases, symptomatic therapy alone with drugs such as oclacitinib is insufficient to control allergies long-term. She has a master's degree in animal science from the University of Delaware and graduated from the University of Pennsylvania School of Veterinary Medicine in 1982. Renal Anemia, or . Like most treatments, this medication will not be successful in every horse, but if it does work, it avoids the risks associated with steroids. After completing a doctorate thesis and a rotating internship at the University of Zurich, Switzerland, he moved to the United States, where he completed a 3-year veterinary dermatology residency at the University of Georgia in 2004. See how Apoquel works differently from steroids and cyclosporines, Discover how Apoquel can relieve allergic itch through an 8-week food trial, Hear from your peers about why Apoquel is their first choice for allergic itch relief, Explore the United States of Apoquel to see how Apoquel has benefited veterinarians in your region, Hear real stories of allergic itch relief from pet owners, See how Zoetis Petcare Rewards can benefit your practice, Informational resources for you to download and utilize within your practice, Provide additional information about Apoquel to pet owners with these resources, Continue therapy once daily (SID) thereafter for maintenance. Its an annoying pill schedule to keep track of, but my boarding barn has been great about it. Your Price: $2.20. Vet Dermatol 2018:29:371 (abstract). This would be treatment with a systemic steroid (usually dexamethasone or prednisolone). However, the twice-daily use must not last for more than 14 days. Apoquel can only be obtained with a prescription; it is available as film-coated tablets and chewable tablets in different strengths to cover a range of dog weights. She gets it all year long since she has a full list of allergies including dust, feathers, and cat dander along with grasses. Recently, we have found that latex, which is everywhere in the horses environmentembedded in riding surfaces and racetracks, for examplemay be associated with severe equine asthma, he says. Im currently struggling with my horses allergies. During this period, the drug is administered twice daily, with an interval of 12 hours. APOQUEL tablets may be administered with or without food. 3. Haugh IM, Watson IT, Menter MA. In the first pilot study, oclacitinib (0.4 to 0.6 mg/kg, q12h for 14 days, then q24h for 14 days) was used to treat pruritus in cats with non-flea, nonfood-induced hypersensitivity dermatitis. The most common side effects associated with Apoquel are vomiting, diarrhea, and lethargy. Also. Freedom of Information Summary NADA 141-345 Apoquel starts working within 4 hours of administering the first dose and controls itching within 24 hours. 405 HERON DRIVE SUITE 200 SWEDESBORO, NJ 08085-1749 | 2004-2023 WEDGEWOOD PHARMACY, ALL RIGHTS RESERVED. APOQUEL FOR DOGS DOSE. He stayed on as a faculty member until 2013, when he decided to move back to Switzerland to open his own dermatology clinic in his hometown of Basel in 2014. A horse can hypothetically be allergic to anything he touches, inhales, ingests, or has applied to or injected into his body. Read on below! Apoquel is typically administered in tablet form at 0.4-0.6mg per kilo of body weight, or 0.18-0.27mg per pound of body weight, every 12 hours or twice a day. Recently, one group has looked into immunomodulatory properties of oclacitinib by observing canine T-cell proliferation and cytokine productions in vitro. While relatively safe for use in most horses, these potent anti-inflammatory drugs can cause a serious potential side effect in some individuals: an increased risk of developing the debilitating hoof disease laminitis. How Should It Be Given? When your dog (cat, horse, child) reacts violently to everyday things like; flea saliva (even from one solitary flea) . J Biol Chem 2007;282(28):20059-20063. Cosgrove SB, Cleaver DM, King VL, et al. A blinded, randomized, placebo-controlled trial of the safety of oclacitinib in cats. 2. So what else can we do for our Equine Asthma patients? She added, "Studies show that omega-3 fatty acids help horses with equine asthma. Apoquel is a non-hormonal drug for dogs, used for dermatitis of various etiologies, which are accompanied by itching. Apoquel is not FDA approved to use twice daily longer than 14 days. If the horse is allergic to any of them, his immune system elicits a response, and a hive forms at the injection site. Before your vet administers immunotherapy, though, you must identify your horses respiratory and skin allergies. Option 2 is the Aservo Equihaler. Oclacitinib is available in 3 different tablet sizes: 3.6, 5.4, and 16 mg. Pasture-associated equine asthma is most prevalent during the summer in the southeastern U.S. but has been reported worldwide. Posted by Lucile Vigouroux | May 4, 2022 | Article, Diseases and Conditions, Farm and Barn, Hives & Skin Allergies, Horse Care, Medications, Nutrition, Seasonal Care, Skin Problems. All trademarks are the property of Zoetis Services LLC or a related company or a licensor unless otherwise noted. Most commonly, immunotherapy involves injecting gradually increasing doses of a specific allergen subcutaneously (just under the skin), explains White. Im hopeful, however, that I will be able to stretch out more so that Im looking at $250 across 8-10 weeks instead. @vxf111 we were told the same thing for food allergiesthat they did not make serums fot them because they were not very effecttive and the the expectation was that the allergen be removed from the diet. The American company "Zoetis Inc" created the drug Apoquel, which deservedly occupies a leading position among drugs for eliminating itching in dogs, regardless of its etiology. More severe ones, however, can truly take a toll on your horses health and make him miserable.